Pros and cons of INSULIN THERAPY
It’s not a secret for anyone that in big sports there is a problem of using illegal drugs, or doping. And bodybuilding is not an exception to this rule. Moreover, in the minds of the general public, bodybuilding is firmly associated with the use of various medications that help increase muscle mass. Undoubtedly, there is a certain amount of truth in this. As a result, a bodybuilder who is inexperienced in sports terminology and does not have enough information simply rushes between the advice of “seasoned jocks” telling him that without “chemistry” he will never become the big and hypocritical position of most cult magazines, stuffed with advertisements of often dubious supplements and stories – “horror stories” about athletes taking doping. At the same time, the pages of these magazines are full of photos of athletes who clearly used something else in addition to nutritional supplements..
In a situation of information vacuum, athletes who try to achieve results by any means conduct risky experiments with drugs, the price of which is a hospital bed or the acquisition of chronic diseases. And these are not empty words. Trust me, in my almost ten-year career as a bodybuilder, I have encountered similar cases quite often..
If we talk about drugs that can significantly undermine your health, then one of the most powerful hormones, insulin, is beyond competition, and therefore we will talk today about this particular drug.
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To begin with, synthetic insulin is generally a very unusual doping. Why unusual? Yes, because it is not detected by a doping test, and in addition, the lack of reliable information about this drug gives rise to various speculations and rumors around it.
Let’s see why synthetic insulin – the drug for severe diabetes patients – is getting so much attention from bodybuilders of all levels..
I want to make a reservation right away: my article is not a guide to action, but information for thought for thinking athletes. I repeat that experiments with insulin can cost you lost health, if not now, then in a certain number of years..
In the wilds of physiology
In the body of a healthy person, insulin is produced by the pancreas, which consists of two independent parts: its main mass, which secretes digestive juice, and the so-called “islets”, which account for only 1-2% of the total volume of the organ. It is these “islets” that perform the endocrine function, since each of them contains from 80 to 200 hormonally active cells that release hormones into the blood. These cells, depending on the substances they produce, are divided into four types – alpha, beta, delta and PP cells. Alpha cells produce glucagon, beta cells produce insulin, delta cells produce gastrin and somatostatin, and PP cells produce pancreatic polypeptide. I note that we will not consider the substances produced by delta and PP cells, since in the context of this article they are insignificant..
Further, we will have to note that the term “sugar” used in everyday life is far from accurate; in fact, there are many varieties of sugars that differ in their chemical structure. Some of them have a more complex structure fluoxymesterone for sale online drop fat and build bodybuilding, and such sugars are called polysaccharides or complex sugars; the structure of others is simpler, and they are called monosaccharides or simple sugars.
Glucagon, produced by alpha cells, promotes the breakdown of complex polysaccharides and the formation of a simple sugar from them – glucose. In the form of glycogen, glucose is stored “in reserve” in the liver and muscles. In addition, it is in the form of glucose that sugar is present in our blood. Why am I telling all this? Yes, because the main function of insulin is to provide cells with glucose and inhibition of blood sugar due to the absorption of glucose by tissues.
In the human body, hormonal systems function within certain limits, and all vital signs are within certain limits, including blood sugar. Low blood sugar makes you feel hungry. A person takes food (proteins, fats, and carbohydrates), as a result of which the concentration of glucose in the blood rises, and on this signal the pancreas begins to produce insulin. As mentioned above, insulin promotes the penetration of glucose into cells, and its level in the blood decreases rather quickly. This cycle repeats itself several times during the day after each meal. In a healthy person, the pancreas reacts in all cases in the same way – the release of the necessary portion of insulin. There is a special unit for measuring the amount of insulin – IU. In a healthy adult, the total amount of insulin produced by the pancreas is about 200 units, and the rate of insulin synthesis is about 40-50 units per day. The blood buy test prop sugar content of a healthy person ranges from 3.3 to 7.0 mol / l – depending on the time of day.
What happens when synthetic insulin is injected into a healthy person? Before understanding this process, I want to note that serious athletes use a whole combination of synthetic hormones to boost the general anabolic process in the body. This means that in addition to insulin, which mainly affects carbohydrate metabolism, various types of anabolic steroids, somatotropic hormone, thyroid hormone T3 (cytamel) and its analogs are used, aimed at enhancing protein and fat metabolism..
If you introduce a sufficiently large dose of synthetic insulin from the outside, a strong decrease in blood sugar levels occurs, and a so-called state of hypoglycemia occurs, characterized by general weakness, trembling in the legs, loss of attention, and impaired visual images. Sometimes hypoglycemia is accompanied by heavy sweating. Further, loss of consciousness may occur, which then turns into a severe coma. However, this is an extreme option, which it is advisable not to reach. Studies have shown that with the correct use of insulin in combination with other hormones, energy metabolism improves, excessive oxidation of energy substrates decreases and their recovery increases, food digestibility and appetite increase, muscles are maximally “full”, and vascularity increases..
Due to the state of moderate hypoglycemia, a protective reaction arises in the human body – an increase in the release of growth hormone. In some cases, the level of growth hormone may increase 5-7 times compared to the norm. The use of anabolic steroids enhances the effect of synthetic insulin: protein metabolism increases sharply, the synthesis of matrix proteins, RNA and DNA is enhanced. In addition, the permeability of cell membranes for amino acids, trace elements and glucose increases. There is an increase in the activity of the pentose phosphate cycle, where the synthesis of parts of protein molecules and carbohydrates occurs. I will also add that a positive feature of insulin is that, being a strong anabolic agent, it can be used in both men and women without causing a virilizing effect (increased hair growth on the face and body, coarsening of the voice, etc.). In this case, as a rule, insulin does not cause allergic reactions..
Watch out for fat!
I would like to point out that the use of synthetic insulin also contributes to the powerful synthesis of adipose tissue throughout the body. The fact is that excess insulin, combined with an unbalanced diet and an excess of simple carbohydrates, activates certain enzymes that convert nandrolone decanoate in bodybuilding 12 week muscle glucose into glycerol, which is deposited in fat stores. Once I found myself in one of our former republics and met the guys from the local athletic club. So: they all looked more like sumo wrestlers than bodybuilders. As it turned out later, they all sat tightly on insulin….
To inhibit the formation of fat, serious athletes use a powerful fat-burning combination of cytomel and clenbuterol in insulin therapy. This combination is excellent at burning fat, even if you consume a lot of calories and sometimes allow yourself to break your diet. Medical specialists studying this problem generally recommend the use of Cytomel in such cases, since the combined action of steroids and insulin lowers the function of the thyroid gland. Another fat burning factor in the use of insulin is the inclusion of growth hormone, or growth hormone, in the cycle, since in addition to its pronounced anabolic effect on the muscles, it also works as a powerful lipotropic. Still, I would advise people who are obese or overweight not to use synthetic insulin. For those who have started a dangerous game with insulin, I advise you to stick to a fairly strict diet..
Insulin and diet
The intake of carbohydrate food should not reach such amounts that stop hypoglycemia completely, otherwise the release of growth hormone will stop.
You need to learn how to vary your carbohydrate intake so that you still feel mild (!) Hypoglycemia without the risk of going into a hypoglycemic coma. That is why it is advisable to take carbohydrates with a low glycemic index in combination with a protein-carbohydrate mixture such as mega-gainers. You should also try to completely eliminate foods containing saturated fatty acids (animal fats) from the diet. In addition, the diet should contain a sufficient amount of complete protein (at least 2.5 grams per kilogram of weight), vitamins and minerals. It’s not a bad idea to include aerobic activity during this period (at least 20 minutes).
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When and how much?
If you get an ampoule of insulin in your hands, do not try to quickly insert it under your skin. Before doing this, try to find out a number of characteristics of this drug..
1. Name, firm and country of origin. A fairly large number of insulin preparations are produced in Russia, however, preference should be given to Western European manufacturers.
2. The type of insulin (bovine, porcine, or human). Human insulin is usually preferred.
3. Characteristics of the duration of insulin exposure (short, intermediate, long-acting or mixed type). An extremely short (!) Action drug is used for anabolic purposes..
4. The concentration of the drug. Insulin activity is expressed in units (U). Insulin is released in different concentrations, that is, one ml of the drug may have a different number of insulin units – 40, 80, 100, 500 U / ml. In Russia, as in a number of European countries, a concentration of 40 U / ml is adopted..
5. Method of packing insulin. A vial, from where the drug must be drawn into a syringe, or a penfill sleeve designed for a pen.
A standard syringe for insulin injections is designed for one milliliter of insulin at a concentration of 40 U / ml, that is, when it is completely filled, it can hold one milliliter of insulin. The marking on the syringe body is applied in insulin units and in single steps, and in numbers from 5 to 40. One 10 ml vial contains 400 units of insulin.
Injections are made subcutaneously in the abdomen. It is from this place that 90% of the administered dose of insulin goes to work and, in addition, insulin begins to act faster. For comparison: after injection into the arm or leg, 70% of the dose is absorbed, and 30% into the scapula.
Short-acting synthetic insulin begins to work, as a rule, 30 minutes after administration, reaches its limit of effect after 1-3 hours and remains active for up to six to eight hours. I would like to note that the reaction to the introduction of insulin in each person is purely individual. Therefore, the initial dose should not exceed 4 units..
As a rule, athletes use the following scheme of insulin administration: from 4 to 12 units once a day or twice a day from 4 to 8 units in the morning and evening. However, this dose can fluctuate depending on the individual sensitivity of the organism. I want to note that the state of hypoglycemia should not interfere with the normal functioning of the body and affect training, work and rest..
Always pay attention to the numbers, because the result of the error lies in a narrow range between hypoglycemia and death.!
The work cycle diagram used by chemical athletes in the off-season during the day:
Anabolic steroids (oral and injectable): approximately 200 mg of active ingredient, depending on the phase;
Short-acting insulin humulin B: about 6 units twice a day;
Triiodothyronine (Cytomel): 100-150 mcg two to three times a day
Growth hormone (growth hormone): approximately 4-6 units two to three times a day, one hour after the injection of insulin;
Chromium picolinate: approximately 500-1,000 mcg 1-2 times a day (dramatically increases the membrane permeability of insulin-dependent cells).
Instead of a conclusion
Now you have some idea of what insulin is and how to use it in bodybuilding. However, don’t jump to conclusions. Yes, insulin is a powerful muscle growth anabolic. However, the consequences of its use can be unpredictable. And before you start this dangerous game, think, is it worth it? One of the greatest bodybuilders
XX century American Steve Reeves built his muscles without any “pharmacology” and, nevertheless, is still considered a living symbol of bodybuilding. So, after thoroughly studying this article, I repeat, do not jump to conclusions and try to make the right choice..